19. The association between pre-transplant SIPAT-score and transplant related outcomes in lung and liver transplant patients: a retrospective cohort study

T.W. Norder, L.S. Derksen, C. Oosterhoff, A. Hoogendoorn, C.T. Gan, A.P. van den Berg, W. van der Bij

Thursday 5 march 2020

0:00 - 0:00h at Toon Hermans Foyer

Parallel session: Postersessie 5 – Klinische en Verpleegkundige abstracts

Background: Psychosocial assessment has become a standard part of the organ transplantation assessment process. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) is a tool to conduct a structured pre-transplant psychosocial assessment. So far, little is known about the relationship between the SIPAT-score and outcomes after transplantation. This study aimed to examine the association between pre-transplant SIPAT-score and clinical and psychosocial outcomes in Dutch lung and liver transplant recipients at one year after transplantation.

Methods: A retrospective cohort study was performed among adult lung (n=57) and liver (n=61) transplant patients who received an organ transplant in 2016 or 2017 within the University Medical Center Groningen. SIPAT-scores and clinical data were retrieved by medical record review. Psychosocial outcome data were retrieved from the TransplantLines Biobank & Cohort study database. Data were analyzed using Spearman’s rho and Mann-Whitney U-test.

Results: The median SIPAT-score was 11 (range 1-70). The median SIPAT-scores differed significantly (p = 0.002) between the lung and liver transplant candidates, respectively 9 (1-42) and 15 (2-70). No significant correlations were found between the SIPAT-score and clinical data regarding duration of the post-transplant hospitalization (p=.35), survival (p=.51), graft survival (p=.34), rejection (p=.45), unplanned hospital readmissions (p=.67) and number of days re-hospitalized (p=.28). Transplant recipients who were rated as minimally acceptable to poor candidates (SIPAT-scores ≥ 21) showed a higher level of anxiety (p=.02) when compared to excellent to good candidates (SIPAT-score ≤ 20) at one year after transplantation. Regarding depression (p=.21), medication adherence (p=.99) and physical and mental quality of life (p=.33 and p=.53) no significant differences were found between these groups.

Conclusions: Except for level of anxiety, the SIPAT-score was not found to be of influence on clinical and psychosocial outcomes at one year post-transplant. Examination of the association of separate SIPAT domains and items with clinical and psychosocial outcomes is needed to gain more in-depth insights.