13. Intraoperative indocyanine green plasma disappearance rate as predictor for retransplantation in liver transplantation

L.C. Pietersen, W.M. Nijboer, H. Putter, B. van Hoek, A.E. Braat, I.P.J. Alwayn, M. Reekers

Wednesday 4 march 2020

0:00 - 0:00h at Toon Hermans Foyer

Parallel session: Postersessie 3 – Klinische abstracts

Background: Liver transplantation (LT) is the treatment of choice for end-stage liver disease and hepatocellular cancer. In case of irreversible graft failure, retransplantation is the only viable treatment option. Early detection of postoperative graft failure may help for timely listing for retransplantation. Unfortunately, no such simple and specific early predictor of graft failure is yet available. The aim of this study was to evaluate whether poor initial function of the liver could be predicted by intraoperative indocyanine green plasma disappearance rate (ICG-PDR) as measured by the need for one-month retransplantation in LT.

Methods: Between January 2010 and May 2017 all orthotopic, first LTs (n=197) performed in a single center were retrospectively analyzed.

Results: LTs with an ICG-PDR <18%/min had a significantly higher one-month retransplantation rate (5%), compared to an ICG-PDR ≥18%/min (1%, logrank p=0.04). The positive predictive value of a K

Conclusions: In conclusion, K<18%/min is a significant risk-factor for one-month retransplantation. However, it has a low predictive value and is therefore not useful in clinical practice.